ABSTRACT
Protein S is a multifunctional plasma protein, whose deficiency, results in a rare congenital thrombophilia, inherited in an autosomal dominant pattern. It can aggravate the hypercoagulable state of pregnancy, when it presents in parallel with the condition, leading to adverse maternal outcomes and foetal loss. A 35-year-old female third gravida having previous 2 deliveries by Lower Segment Caesarean Section (LSCS) presented to emergency at 10 weeks pregnancy with chief complaints of pain and swelling in left thigh since 4-5 days. After thorough investigations and work-up, the patient was diagnosed with Protein S deficiency. She was managed conservatively and was delivered by elective LSCS with bilateral tubal ligation at 38 weeks of gestation with good foetal and maternal outcomes.The rarity of Protein S deficiency along with the successful outcome of the pregnancy makes this a unique case.Copyright © 2023 Journal of Clinical and Diagnostic Research. All rights reserved.
ABSTRACT
Background: At the onset of Covid-19 pandemic, it was an unknown entity in terms of risk status of the pregnant women for fetomaternal outcome. Both fetus and pregnant women were considered as groups under special concern due to their unique physiological characteristics. Method(s): A retrospective study was conducted in department of Obstetrics & Gynaecology along with Paediatrics department in Maharishi Markandeshwar Medical College and Hospital, Solan on pregnant females admitted to the Covid-19 Ward/ ICU over a period from August 2020 till 31st March 2022. Participants were included into 3 waves of pandemic based upon time of presentation and these 3 groups were further studied for the various fetomaternal parameters such as maternal age, symptom status, need for respiratory support, maternal mortality, abortions, still births, gestational age and weight of newborn and other morbidity and mortality in newborns. Result(s): A total of 171 pregnant were included in the study, of whom 47, 64 and 60 were seen in 1st, 2nd and 3rd waves respectively. Majority of subjects were asymptomatic in 1st, 2nd & 3rd wave, (p=0.30). Age wise distribution of the patients showed majority subjects in the age group of 20-30 years (p= 0.94). LSCS rates in 3 waves were not different significantly (p = 0.67). Maternal mortality rates and need for respiratory support were in similar proportions in all 3 waves (p=0.71) and (p=0.73) respectively. No significant difference was seen in maternal morbidity and neonatal outcome. Conclusion(s): The study showed no significant difference between the waves of Covid-19 pandemic in terms of fetomaternal outcome except no maternal mortality in 3rd wave. Copyright © 2022 Ubiquity Press. All rights reserved.
ABSTRACT
BACKGROUND: On December 31, 2019, several cases of pneumonia-like illness were attributed to a seafood wholesale market in the Wuhan province of China. On January 7, 2020, public health officials in China confirmed that these cases were caused by the novel severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, also referred to as covid-19. As of December 19, 2021, there have been approximately 827,246 deaths and 51,723,483 cases in the United States. Covid-9 has disproportionately affected the underserved communities. On December 14, 2020, the first coronavirus vaccine was given in United States to Sandra Lindsey, an ICU nurse, in New York City. As of December 19, 2021, approximately 241,205,528 or 72.7% of the population has received at least one dose and overall 203,727,446 or 61.4% of the population has been fully vaccinated against the coronavirus. Mississippi has among the lowest rates of covid-19 vaccination with approximately 1,435,238 or 47% of population being fully vaccinated on December 17, 2021. METHODS: Medical records of all patients admitted at Baptist Memorial Hospital in Desoto, Mississippi. with a diagnosis of covid-19 infection between May 2021 and October 2021 were reviewed. EPIC electronic health records system was used to obtain the patient information. Covid-19 rapid antigen and PCR test results were used for analyzing the information. Patient charts were analyzed to retrieve specific vaccination information: no vaccination, one vaccine, two vaccines, time of last vaccination. Only adults aged 18 years and older were included in this study. RESULTS: 180 of 187 inpatients admitted for Covid-19 infection denied any history of Covid-19 vaccination. 5 of 7 vaccinated patients admitted for Covid19 infection were immunocompromised (cancer chemotherapy, immunosuppressive therapy, etc). Only 2 of vaccinated patients admitted for Covid-19 infection were not immunocompromised. CONCLUSIONS: The best way to prevent coronavirus infection is to get vaccinated. Vaccination prevents mortality and severe illness from Covid-19 infection requiring inpatient hospitalizations. Our study at the largest tertiary care hospital in Desoto, Mississippi, finds that nearly all patients admitted with Covid-19 infection during our study period were either unvaccinated or immunocompromised. Our study reaffirms the that if enough people get vaccinated, the viral transmission rate will slow sand there will be less morbidity and mortality. People who are fully vaccinated are at a much lower risk of getting the virus. “Fully vaccinated” means you have had all doses of the vaccine and it has been at least 2 weeks since the last dose.
ABSTRACT
PURPOSE: The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID-19 either on seminal or hormonal parameters. The safety of the COVID-19 vaccines in terms of sperm quality was also investigated. METHODS: All prospective and retrospective observational studies reporting information on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) mRNA semen and male genitalia tract detection (n = 19), as well as those reporting data on semen analysis (n = 5) and hormonal parameters (n = 11) in infected/recovered patients without any arbitrary restriction were included. RESULTS: Out of 204 retrieved articles, 35 were considered, including 2092 patients and 1138 controls with a mean age of 44.1 ± 12.6 years, and mean follow-up 24.3 ± 18.9 days. SARS-CoV-2 mRNA can be localized in male genitalia tracts during the acute phase of the disease. COVID-19 can result in short-term impaired sperm and T production. Available data cannot clarify long-term andrological effects. Low T observed in the acute phase of the disease is associated with an increased risk of being admitted to the Intensive Care Unit or death. The two available studies showed that the use of mRNA COVID-19 vaccines does not affect sperm quality. CONCLUSIONS: The results of our analysis clearly suggest that each patient recovering from COVID-19 should be monitored to rule out sperm and T abnormalities. The specific contribution of reduced T levels during the acute phase of the infection needs to be better clarified.
Subject(s)
COVID-19 , Male , Humans , Adult , Middle Aged , SARS-CoV-2 , COVID-19 Vaccines , Prospective Studies , Retrospective Studies , Semen , RNA, MessengerABSTRACT
BACKGROUND: During the pandemic, disruption of work schedule and constant health risks causes physician burnout. This study aims to identify Burnout in physicians working in COVID ICU and isolation Ward. METHODS: A cross-sectional study was conducted on 200 physicians who had worked in either COVID ICU or Isolation ward. A survey of 23 questions was designed to assess the work-related Burnout using the Copenhagen burnout inventory and the implementation of NIH guidelines. RESULTS: Among the 200 physicians, 151 (75.5%) were well informed of the guidelines, of which 52 (34.4%) participants believed the guidelines were not sufficient. These 34.4% of individuals showed a mean burnout score of 70.05% (p-value 0.001). Medical registrars and Medical Officers suffered the highest burnout mean percentage score of 76% and 72.42%, respectively. 89 (44.5%) individuals arranged PPE suits on their own and suffered a burnout score of 71.3% ±14.35 (p-value <0.001). Seventy-two (36%) claimed their administration was not cooperative in resolve safety issues. These individuals showed a mean burnout score of 74.3% ±13.82 (p-value <0.001). CONCLUSIONS: Lack of physician's faith in the adequacy of the NIH guidelines has been found to be a significant factor in contributing to work-related Burnout. Due to the shortage of PPE, a majority of physicians have to reuse their PPE multiple times and even have to personally arrange their PPE suits, which further compounds the burnout. Increase administrative cooperation in resolving issues related to safety measures should help elevate work-related burnout in physicians working in the ICU and isolation ward.
ABSTRACT
Objective: To evaluate the psychological fear (anxiety) of dental patients while visiting a dentist in the period of the present coronavirus disease (COVID-19) pandemic. Methodology: This online cross-sectional survey used a self-administered questionnaire to analyze the anxiety, knowledge, and perception of 461 dental patients. A p<0.05 was considered significant. Results: Data from 461 participants revealed significant differences among genders (X-2 = 14.944, p<0.001), age (X-2= 142.915, p<0.001), and between the educational levels of the participants (X-2= 410.399, p<0.001). We found that 63.6% patients were afraid of visiting dentists due to the fear of COVID-19, and 66.2% patients thought that they will get the disease from the dentist or dental office. We observed that females were found to be more anxious than men (p<0.05). Conclusion: There was high anxiety among the patients to visit dentists because of the current pandemic. Aanxiety regarding COVID-19 is prevalent in the society that may lead to a monetary crisis for dentists.